VALIDATION OF CANDIDATE HOST CELL ENTRY FACTORS FOR BOVINE HERPES VIRUS TYPE-1 BASED ON A GENOME-WIDE CRISPR KNOCKOUT SCREEN

Validation of Candidate Host Cell Entry Factors for Bovine Herpes Virus Type-1 Based on a Genome-Wide CRISPR Knockout Screen

To identify host factors that affect Bovine Herpes Virus Type 1 (BoHV-1) infection we previously applied a genome wide CRISPR knockout screen targeting all bovine protein coding genes.By doing so we compiled a list of both pro-viral and anti-viral proteins involved in BoHV-1 replication.Here we provide further analysis of those that are potentially

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C-5 Hydroxyethyl and Hydroxypropyl Acyclonucleosides as Substrates for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK): Syntheses and Biological Evaluation

The efficient syntheses of 5-(2-hydroxyethyl)- and 5-(3-hydroxypropyl)-substituted pyrimidine derivatives bearing 2,3-dihydroxypropyl, acyclovir-, ganciclovir- and penciclovir-like side chains are reported.A synthetic approach that included the alkylation of an N-anionic-5-substituted pyrimidine simply southern cat shirt intermediate (method A) pro

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Sale of Getback Bonds as an Example of Misselling

The purpose of this article.The purpose of this study is to identify the occurrence of misselling in the process of offering and selling corporate bonds of GetBack SA.Methodology.The study included a literature review, analysis of secondary data derived from official documents such as decisions issued by the President of the Office of Competition a

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